Has anyone tried pi high quality camera.
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It will not be a drop-in replacement in the Openflexure microscope as the sensor is bigger and the board is bigger. It is an exciting prospect though - the bigger pixels should give better signal-to-noise even for the same underlying sensor quality and put slightly less requirement on the quality of the tube lens.
Raspberry Pi have confirmed that the C-mount part is removable, which makes the board even easier to integrate into projects like this.